Clio started making films at film school at the London College of Printing, and after graduating she wrote and directed Shrine, a short film which won the 1995 Kodak Award.

She went on to work at the Institute of Contemporary Arts for three years, where she filmed and directed a large part of a unique 2000 hour British Film Institute archive documenting visiting artists and writers, including Jaques Derrida, Will Self, Anthony Minghella and many others.

Clio started working at Twenty Twenty television in 1999 on a Cutting Edge and a number of other high profile documentaries for Channel 4, BBC and National Geographic. In 2002 she developed and directed her first documentary for Channel 4 - Cannabis Psychosis, which took a first major look into the effects of cannabis on mental health.

She went on to work at Roger Graef’s company, Films of Record, where she made a Storyville film for BBC4 and BBC Scotland, Who am I now?, about the effects of former news reader Sheena McDonald’s brain injury on her life and identity.

Other films include Being Brian Harvey for BBC1’s One Life documentary strand, Arthur and Anita for BBC3’s Country Strife series, Freebirthing for Channel 5 and 'Georgia’s Story: 33 stone at 15, which was shown on BBC1 and BBC3 as part of the mental health season, Headroom. She directed on Channel 4’s multi-platform documentary series, Seven Days, which was filmed, edited and transmitted weekly, and for BBC2s landmark series 'Keeping Britain Alive', filming the work of the NHS across the country in a single 24 hours. Most recently she made a documentary for BBC1, My Big Beautiful Wedding Dress, broadcast in 2014.

She makes mainly single documentaries, often filming them herself, and is currently developing a number of projects.